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Phiên bản vào lúc 12:44, ngày 15 tháng 10 năm 2020 của TammaraGrainger (Thảo luận | đóng góp) (Tạo trang mới với nội dung “The dominance of the PRLR mutation is also curious, since truncation of 120 C terminal amino acids could be expected to result in a loss of function. Prol…”)

The dominance of the PRLR mutation is also curious, since truncation of 120 C terminal amino acids could be expected to result in a loss of function. Prolactin receptor knockout mice exhibit marginally larger diameter hair, although other phenotypes are reminiscent of hairy syndrome cattle, namely longer hair fibres, and failure to lactate9,13. An example of a functionally coupled, C terminal PRLR mutant has recently been described in chickens, where, notably, this variant has been proposed as the causative mutation underlying a dominantly inherited feather growth retardation phenotype22.

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